Here are the podcasts I regularly follow:
Mac Power Users – David Sparks and Katie Floyd present workflows, tips and tricks, and basically all things Mac in this weekly podcast on the 5by5 network.
Back to Work – Merlin Mann and Dan Benjamin are supposed to be discussing productivity and work strategies, but often wind up talking about tips and tricks to get out public restrooms unscathed, Adventure Time, comic books, and other things classified as “monkeyballs”. Way of the future.
The Smartest Man In the World (Greg Proops) – this explicit “Vodcast” touches of all manner of travel, art, literature, and politics.